Trans-ethnic association study of blood pressure determinants in over 750,000 individuals

- Giri, Ayush; Hellwege, Jacklyn N.; Keaton, Jacob M.; Park, Jihwan; Qiu, Chengxiang; Warren, Helen R.; Torstenson, Eric S.; Kovesdy, Csaba P.; Sun, Yan V.; Wilson, Otis D.; Robinson-Cohen, Cassianne; Roumie, Christianne L.; Chung, Cecilia P.; Birdwell, Kelly A.; Damrauer, Scott M.; DuVall, Scott L.; Klarin, Derek; Cho, Kelly; Wang, Yu; Evangelou, Evangelos; Attia, John; Oldmeadow, Christopher; Wei, WQ; Jarvelin, MR; Hennig, BJ; Timpson, NJ; Smith, JC; Xu, Y; Matheny, ME; Siew, EE; Lindgren, C; Herzig, KH; Dedoussis, G; Denny, JC; Psaty, BM; Howson, JMM; Munroe, PB; Newton-Cheh, C; Caulfield, MJ; Elliott, P; Gaziano, JM; Concato, J; Wilson, PWF; Tsao, PS; Velez Edwards, DR; Susztak, K; O¿Donnell, CJ; Hung, AM; Edwards, TL; Cabrera, Claudia P.; Wain, LV; Shrestha, R; Mautz, BS; Akwo, EA; Sargurupremraj, M; Debette, S; Boehnke, M; Scott, LJ; Luan, J; Zhao, JH; Willems, SM; Thériault, S; Shah, N; Almgren, P; Li-Gao, R; Verweij, N; Boutin, TS; Mangino, M; Ntalla, I; Feofanova, E; Surendran, P; Cook, JP; Karthikeyan, S; Lahrouchi, N; Liu, C; Sepúlveda, N; Richardson, TG; Kraja, A; Amouyel, P; Farrall, M; Poulter, NR; Laakso, M; Zeggini, E; Sever, P; Scott, RA; Langenberg, C; Wareham, NJ; Conen, D; Palmer, CNA; Chasman, DI; Ridker, PM; Melander, O; Mook-Kanamori, DO; van der Harst, P; Cucca, F; Schlessinger, D; Hayward, C; Spector, TD

Title
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals
Creator
Giri, Ayush; Hellwege, Jacklyn N.; Keaton, Jacob M.; Park, Jihwan; Qiu, Chengxiang; Warren, Helen R.; Torstenson, Eric S.; Kovesdy, Csaba P.; Sun, Yan V.; Wilson, Otis D.; Robinson-Cohen, Cassianne; Roumie, Christianne L.; Chung, Cecilia P.; Birdwell, Kelly A.; Damrauer, Scott M.; DuVall, Scott L.; Klarin, Derek; Cho, Kelly; Wang, Yu; Evangelou, Evangelos; Attia, John; Oldmeadow, Christopher; Wei, WQ; Jarvelin, MR; Hennig, BJ; Timpson, NJ; Smith, JC; Xu, Y; Matheny, ME; Siew, EE; Lindgren, C; Herzig, KH; Dedoussis, G; Denny, JC; Psaty, BM; Howson, JMM; Munroe, PB; Newton-Cheh, C; Caulfield, MJ; Elliott, P; Gaziano, JM; Concato, J; Wilson, PWF; Tsao, PS; Velez Edwards, DR; Susztak, K; O¿Donnell, CJ; Hung, AM; Edwards, TL; Cabrera, Claudia P.; Wain, LV; Shrestha, R; Mautz, BS; Akwo, EA; Sargurupremraj, M; Debette, S; Boehnke, M; Scott, LJ; Luan, J; Zhao, JH; Willems, SM; Thériault, S; Shah, N; Almgren, P; Li-Gao, R; Verweij, N; Boutin, TS; Mangino, M; Ntalla, I; Feofanova, E; Surendran, P; Cook, JP; Karthikeyan, S; Lahrouchi, N; Liu, C; Sepúlveda, N; Richardson, TG; Kraja, A; Amouyel, P; Farrall, M; Poulter, NR; Laakso, M; Zeggini, E; Sever, P; Scott, RA; Langenberg, C; Wareham, NJ; Conen, D; Palmer, CNA; Chasman, DI; Ridker, PM; Melander, O; Mook-Kanamori, DO; van der Harst, P; Cucca, F; Schlessinger, D; Hayward, C; Spector, TD
Relation
Nature Genetics Vol. 51, Issue 1, p. 51-62
Publisher Link
http://dx.doi.org/10.1038/s41588-018-0303-9
Publisher
Nature Publishing Group
Resource Type
journal article
Date
2019
Description
In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in genome-wide association studies of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program (MVP) and collaborating studies, with analysis of the blood pressure clinical phenome in MVP. Our transcriptome-wide association study detected 4,043 blood pressure associations with genetically predicted gene expression of 840 genes in 45 tissues, and mouse renal single-cell RNA sequencing identified upregulated blood pressure genes in kidney tubule cells.
Subject
trans-ethnic; blood pressure determinants; genes; kidney tubule cells
Identifier
http://hdl.handle.net/1959.13/1444996
Identifier
uon:42468
Identifier
ISSN:1061-4036
Language
eng
Reviewed
  • Hits: 27021
  • Visitors: 27008
  • Downloads: 1
Thumbnail File Description Size Format
  • Disclaimer
  • Privacy
  • Copyright
  • Contact
  • Deposit